Theophylline to restore a sense of smell
A drug based on theophylline has shown promising results in restoring the sense of smell to those who have lost.
The administration of theophylline, a drug already known for some time in the treatment of bronchial asthma, is effective in patients with hyposmia, also known as viral anosmia, nasal secretion with low concentrations of c-AMP, the factor growth of epithelial cells. The drug, can block the enzyme phosphodiesterase capable of reducing the c-AMP can restore the proper level of c-AMP and promote the recovery smell. According to Dr. . Robert Henkin, author of the article published in the June American Journal of Medical Sciences, there are few effective remedies.
Henkin, director of the Center for Molecular Nutrition and Sensory Disorders in Washingotn DC, with his staff had established that people with hyposmia had reduced levels of cyclic nucleotides in the saliva and nasal mucosa, and that treatment with theophylline changed by increasing c-AMP levels in saliva and nasal mucosa, restoring the sense of smell. Now the second Henkin results need to be tested in clinical trials. For
dr. Kuppersmith Ronald, professor of surgery at Texas A & M Health Science Center College of Medicine and president of the American Academy of Otolaryngology-Head and Neck Surgery "for those who have no other effective treatments, this may be a viable option." The
hyposmia in the United States makes about 20 million people with no smell, is caused by viruses, head injuries, severe allergies or certain types of anatomical obstruction of the nose or nasal polyps.
Side effects of theophylline, second minimum, the researchers report nervousness and agitation as well as difficulty falling asleep. HealthDay - July 10, 2009
nb Theophylline is an alkaloid found in tea leaves (Camellia sinensis), but also in coffee beans and guarana. Its concentration varies widely in relation to the type, variety and duration of the infusion.
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